What is the most common antidote used in the case of Acetaminophen toxicity?

N-acetylcysteine is the most common antidote used for acetaminophen toxicity because it works specifically to replenish glutathione levels in the liver, ultimately helping to detoxify the harmful metabolites produced during an overdose. In cases of acute acetaminophen toxicity, the liver's ability to process the drug becomes overwhelmed, leading to cellular damage. N-acetylcysteine acts as a precursor to glutathione, which is a critical antioxidant that helps to neutralize the toxic byproducts of acetaminophen.

Timely administration of N-acetylcysteine, ideally within 8 to 10 hours of ingestion, is crucial for preventing severe liver damage and potential liver failure. It can effectively prevent the progression of liver injury if given early enough, which emphasizes its role as the first-line treatment.

Other antidotes mentioned, such as activated charcoal, can serve as a treatment option to limit absorption if administered shortly after ingestion but do not actively counteract the toxicity. Morphine is an opioid pain medication not related to acetaminophen toxicity and would not be used to treat overdose situations. Similarly, digoxin immune Fab is specific for digoxin poisoning and is not relevant in cases of acetaminophen toxicity. Therefore, N-ac