Which drug is known to cause priapism?

Which drug is known to cause priapism?

• A. Trimethoprim
• B. Trazo done
• C. Fentanyl
• D. Ibuprofen

Answer: (B)

Priapism is a prolonged and often painful erection that lasts for several hours and can occur without sexual stimulation. It is generally associated with certain medications and medical conditions. Among the choices provided, trazodone is the drug most commonly linked to causing priapism. Trazodone is an antidepressant that primarily acts as a serotonin antagonist and reuptake inhibitor. One of its side effects is the potential induction of priapism, particularly in males taking higher doses. The exact mechanism by which trazodone causes priapism isn't fully understood, but it is thought to involve the drug's effect on serotonin receptors and other signaling pathways that may influence penile vasculature. In contrast, the other drugs listed—trimethoprim, fentanyl, and ibuprofen—do not have a well-established connection to the incidence of priapism. Trimethoprim is an antibiotic, fentanyl is an opioid analgesic, and ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). None of these are known to have side effects related to prolonged erections as seen with trazodone. This distinctive association of trazodone with priapism highlights its significance in the context of these medications, especially when treating patients who

Priapism is a prolonged and often painful erection that lasts for several hours and can occur without sexual stimulation. It is generally associated with certain medications and medical conditions. Among the choices provided, trazodone is the drug most commonly linked to causing priapism.

Trazodone is an antidepressant that primarily acts as a serotonin antagonist and reuptake inhibitor. One of its side effects is the potential induction of priapism, particularly in males taking higher doses. The exact mechanism by which trazodone causes priapism isn't fully understood, but it is thought to involve the drug's effect on serotonin receptors and other signaling pathways that may influence penile vasculature.

In contrast, the other drugs listed—trimethoprim, fentanyl, and ibuprofen—do not have a well-established connection to the incidence of priapism. Trimethoprim is an antibiotic, fentanyl is an opioid analgesic, and ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). None of these are known to have side effects related to prolonged erections as seen with trazodone. This distinctive association of trazodone with priapism highlights its significance in the context of these medications, especially when treating patients who